Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery

Defibrillation of bacterial cellulose by ultra-refining was efficient to release nanofibers (BCNF) which were spray dried with the matrices formers mannitol (MN), maltodextrin or hydroxypropylmethylcellulose. The best microsystem comprised the association of BCNF and MN, so the selected microparticl...

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Detalhes bibliográficos
Autores: Meneguin, Andreia Bagliotti [UNESP], Barud, Hernane da Silva, Sabio, Rafael Miguel [UNESP], Sousa, Paula Zanin de, Manieri, Karyn Fernanda [UNESP], Pedro de Freitas, Luis Alexandre, Pacheco, Guilherme, Alonso, Jovan Duran, Chorilli, Marlus [UNESP]
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/210409
Acesso em linha:http://dx.doi.org/10.1016/j.carbpol.2020.116838
http://hdl.handle.net/11449/210409
Access Level:acceso abierto
Palavra-chave:Intestinal drug delivery
Pharmaceutical excipients
Bacterial cellulose nanofibers
Spray drying
Descrição
Resumo:Defibrillation of bacterial cellulose by ultra-refining was efficient to release nanofibers (BCNF) which were spray dried with the matrices formers mannitol (MN), maltodextrin or hydroxypropylmethylcellulose. The best microsystem comprised the association of BCNF and MN, so the selected microparticles were loaded with diclofenac sodium or caffeine. Depending on the proportion of BCNF, the nanofibers collapse promoted by spray drying can occur onto surface or into microparticles core, leading to different release behaviors. Samples showed pH-dependent drug release, so the microsystem developed with the lowest BCNF concentration showed important trend to gastroresistance. Caffeine was spray dried as a free drug and for this reason it was devoid of any control over release rates. The set of results showed BCNF can be considered an interesting and potential pharmaceutical excipient for lipophilic drugs. Beyond that, BCNF association with MN can lead to novel enteric drug delivery systems based on natural polymers.

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