Lactone derivatives produced by a Phaeoacremonium sp., an endophytic fungus from Senna spectabilis

Three new isoaigialones, A, B, and C (1–3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data...

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Bibliographic Details
Authors: Silva, Geraldo H., Zeraik, Maria L., Oliveira, Camila M. de, Teles, Helder L., Trevisan, Henrique C., Pfenning, Ludwig H., Nicolli, Camila P., Young, Maria C. M., Mascarenhas, Yvonne P., Abreu, Lucas M., Saraiva, Amanda C., Medeiros, Alexandra I., Bolzani, Vanderlan da S., Araujo, Angela R.
Format: article
Status:Published version
Publication Date:2017
Country:Brasil
Institution:Universidade Federal de Viçosa (UFV)
Repository:LOCUS Repositório Institucional da UFV
Language:English
OAI Identifier:oai:locus.ufv.br:123456789/19907
Online Access:https://doi.org/10.1021/acs.jnatprod.5b00828
http://www.locus.ufv.br/handle/123456789/19907
Access Level:Open access
Keyword:Phaeoacremonium sp.
Senna spectabilis
Description
Summary:Three new isoaigialones, A, B, and C (1–3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds 2 and 4 were active against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum. This is the first report of metabolites produced by an Phaeoacremonium sp., associated with S. spectabilis.

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