Tuberculosis: an uncommon cause of cerebral venous thrombosis?

Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations.We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black...

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Bibliographic Details
Authors: Fiorot Júnior, José Antonio [UNIFESP], Felício, André Carvalho [UNIFESP], Fukujima, Marcia Maiumi [UNIFESP], Rodrigues, Celso Arrais [UNIFESP], Morelli, Vânia Maria [UNIFESP], Lourenco, Dayse Maria [UNIFESP], Prado, Gilmar Fernandes do [UNIFESP]
Format: article
Status:Published version
Publication Date:2005
Country:Brasil
Institution:Universidade Federal de São Paulo (UNIFESP)
Repository:Repositório Institucional da UNIFESP
Language:English
OAI Identifier:oai:repositorio.unifesp.br:11600/2660
Online Access:http://dx.doi.org/10.1590/S0004-282X2005000500025
http://repositorio.unifesp.br/handle/11600/2660
Access Level:Open access
Keyword:cerebral venous thrombosis
tuberculosis
prothrombin gene mutation
trombose venosa cerebral
tuberculose
mutação do gene da protrombina
Description
Summary:Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations.We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black presented abrupt right hemiparestesis, and hemiparesis. Investigations revealed CVT. Cerebral spinal fluid (CSF) examination evidenced a infection by Mycobacterium. He was heterozygous for G20210A prothrombin mutation. Probably, hypercoagulability mechanisms of TB, added to mutation of prothrombim gene increase the risk of CVT.

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