Synthesis of 2',4,4'-trimethoxychalcon and in vitro cytotoxic study in human tumor cells / Síntese da 2',4,4'-trimetoxichalcona e estudo citotóxico in vitro em células tumorais humanas
Chalcones are a class of natural compounds, aromatic ketones that forms central core for several important pharmacological activities reported such as anticarcinogenicity and antioxidation activities. Due to those important properties, the purpose of this work is the organic synthesis of 2’,4,4'...
| Authors: | , , , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2019 |
| Country: | Brasil |
| Institution: | Instituto Superior de Educação Vera Cruz (VeraCruz) |
| Repository: | Revista Veras |
| Language: | English |
| OAI Identifier: | oai:ojs2.ojs.brazilianjournals.com.br:article/3971 |
| Online Access: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/3971 |
| Access Level: | Open access |
| Keyword: | Chalcone Organic Synthesis Cytotoxicity Aldol Condensation HL-60. |
| Summary: | Chalcones are a class of natural compounds, aromatic ketones that forms central core for several important pharmacological activities reported such as anticarcinogenicity and antioxidation activities. Due to those important properties, the purpose of this work is the organic synthesis of 2’,4,4'-trimethoxychalcone and its cytotoxicity test against four human tumor cell lines: HL-60 (human promyelocytic leukemia), HCT-116 (human colorectal carcinoma), MCF-7 (human breast adenocarcinoma) and K562 (chronic myeloid leukemia) and also evaluated in normal cells L929 (murine fibroblast). The synthesis of 2', 4,4'-trimethoxychalcone was successful and in the viability cell assay (MTT assay), the HL-60 strain was found to have an inhibitory potential of 84.5% and an IC50 of approximately 20.84 µM. |
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