Cardioprotective effects of Baccharis trimera (Less.) DC in a rodent model of hookah, alcohol, and energy drink exposure

This study proposes an unpreceded model of cardiovascular disease by combining alcohol and energy drink intake with hookah smoking to investigate the cardiovascular effects of Baccharis trimera (Less.) DC., a medicinal plant used to treat dyslipidemia. For 10 weeks, Wistar rats (n=8) received alcoho...

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Detalhes bibliográficos
Autores: Amaral, Eduarda Carolina, da Silva, Gustavo Ratti, Braga, Fernanda de Abreu, Palozi, Rhanany Alan Calloi, Lorençone, Bethânia Rosa, Marques, Aline Aparecida Macedo, Moreno, Karyne Garcia Tafarelo, Leite, Patrícia Regina Terço, Barboza, Lorena Neris, Souza, Roosevelt Isaias Carvalho, dos Santos, Ariany Carvalho, Lovato, Evellyn Claudia Wietzikoski, Ribeiro-Paes, João Tadeu [UNESP], Junior, Arquimedes Gasparotto, Lívero, Francislaine Aparecida dos Reis
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/246544
Acesso em linha:http://dx.doi.org/10.37360/blacpma.23.22.3.28
http://hdl.handle.net/11449/246544
Access Level:acceso abierto
Palavra-chave:Alcohol
Baccharis trimera
Cardiovascular diseases
Carqueja
Hookah
Tobacco
Descrição
Resumo:This study proposes an unpreceded model of cardiovascular disease by combining alcohol and energy drink intake with hookah smoking to investigate the cardiovascular effects of Baccharis trimera (Less.) DC., a medicinal plant used to treat dyslipidemia. For 10 weeks, Wistar rats (n=8) received alcohol (10% ad libitum) and energy drink (2 mL/kg) and/or were exposed to hookah smoke (1 hour/day). In the last 4 weeks, the animals received daily treatment with vehicle (filtered water) or ethanol soluble fraction of B. trimera (30, 100 and 300 mg/kg). Electrocardiography was performed. Systolic, diastolic, and mean blood pressure, heart rate, and plasmatic cholesterol, triglycerides, urea, creatine, aspartate, and alanine aminotransferase levels were determinate. The heart, aorta, and kidneys were histopathological evaluated. In isolation the risk factors altered all the evaluated parameters and when the risk factors were associated, a synergistic effect was observed. Treatment with B. trimera reversed these cardiovascular changes.

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