Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil

Trabalho completo: acesso restrito, p.49–56

Detalhes bibliográficos
Autores: Romero, Gustavo Adolfo Sierra, Orge, Maria de la Glória Orge, Guerra, Marcus Vinitius de Farias, Paes, Marcilene Gomes, Macêdo, Vanize de Oliveira, Carvalho Filho, Edgar Marcelino de
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2005
País:Brasil
Recursos:Universidade Federal da Bahia (UFBA)
Repositório:Repositório Institucional da UFBA
Idioma:inglês
OAI Identifier:oai:repositorio.ufba.br:ri/6643
Acesso em linha:http://www.repositorio.ufba.br/ri/handle/ri/6643
Access Level:Acceso aberto
Palavra-chave:Cutaneous leishmaniasis
Antibody response
Indirect immunofluorescent assay
ELISA
Leishmania (Viannia) braziliensis
Leishmania (Viannia) guyanensis
Brazil
id BR_458f472fa63a33a9ea3e4fa2948c0730
oai_identifier_str oai:repositorio.ufba.br:ri/6643
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.pt_BR.fl_str_mv Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
dc.title.alternative.pt_BR.fl_str_mv Acta Tropica
title Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
spellingShingle Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
Romero, Gustavo Adolfo Sierra
Cutaneous leishmaniasis
Antibody response
Indirect immunofluorescent assay
ELISA
Leishmania (Viannia) braziliensis
Leishmania (Viannia) guyanensis
Brazil
title_short Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
title_full Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
title_fullStr Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
title_full_unstemmed Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
title_sort Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil
dc.creator.none.fl_str_mv Romero, Gustavo Adolfo Sierra
Orge, Maria de la Glória Orge
Guerra, Marcus Vinitius de Farias
Paes, Marcilene Gomes
Macêdo, Vanize de Oliveira
Carvalho Filho, Edgar Marcelino de
Romero, Gustavo Adolfo Sierra
Orge, Maria de la Glória Orge
Guerra, Marcus Vinitius de Farias
Paes, Marcilene Gomes
Macêdo, Vanize de Oliveira
Carvalho Filho, Edgar Marcelino de
author Romero, Gustavo Adolfo Sierra
author_facet Romero, Gustavo Adolfo Sierra
Orge, Maria de la Glória Orge
Guerra, Marcus Vinitius de Farias
Paes, Marcilene Gomes
Macêdo, Vanize de Oliveira
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Orge, Maria de la Glória Orge
Guerra, Marcus Vinitius de Farias
Paes, Marcilene Gomes
Macêdo, Vanize de Oliveira
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
dc.subject.por.fl_str_mv Cutaneous leishmaniasis
Antibody response
Indirect immunofluorescent assay
ELISA
Leishmania (Viannia) braziliensis
Leishmania (Viannia) guyanensis
Brazil
topic Cutaneous leishmaniasis
Antibody response
Indirect immunofluorescent assay
ELISA
Leishmania (Viannia) braziliensis
Leishmania (Viannia) guyanensis
Brazil
description Trabalho completo: acesso restrito, p.49–56
publishDate 2005
dc.date.issued.fl_str_mv 2005-02
dc.date.accessioned.fl_str_mv 2012-08-28T19:58:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6643
dc.identifier.issn.none.fl_str_mv 0001-706X
dc.identifier.number.pt_BR.fl_str_mv v. 93, n. 1
identifier_str_mv 0001-706X
v. 93, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6643
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.actatropica.2004.09.005
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/6643/1/%28176%29.pdf
https://repositorio.ufba.br/bitstream/ri/6643/2/license.txt
https://repositorio.ufba.br/bitstream/ri/6643/3/%28176%29.pdf.txt
bitstream.checksum.fl_str_mv 4a2ab50252ad27e6e459a3782a6004e0
1b89a9a0548218172d7c829f87a0eab9
ba213127c776ed33a1e1e5d6adf2d215
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv repositorio@ufba.br
_version_ 1853668565505277952
spelling 2012-08-28T19:58:10Z2005-020001-706Xhttp://www.repositorio.ufba.br/ri/handle/ri/6643v. 93, n. 1Trabalho completo: acesso restrito, p.49–56The antibody response against Leishmania (Leishmania) amazonensis crude antigen was measured through the indirect immunofluorescent assay (IFA) and the immunoenzymatic assay (ELISA) in 114 patients with cutaneous leishmaniasis (CL) in Brazil. Fifty-four patients were infected by Leishmania (Viannia) braziliensis, and 60 patients had L. (V.) guyanensis infection. Patients were comparable by age, sex, disease duration and the Montenegro skin test diameter. L. (V.) braziliensis-infected patients showed significant lower number of ulcerated lesions, greater ulcerated area and higher proportion of lymph node enlargement. Sensitivity of IFA was 79.6% (95% CI 66.1–88.9) and 71.7% (95% CI 58.4–82.2) for L. (V.) braziliensis and L. (V.) guyanensis-infected patients, respectively (P = 0.324). Sensitivity of ELISA was 98.2% (95% CI 88.8–99.9) and 85.0% (95% CI 72.9–92.5) for L. (V.) braziliensis and L. (V.) guyanensis-infected patients, respectively (P = 0.018). Significant differences were observed in the magnitude of the antibody response before treatment with higher levels detected in L. (V.) braziliensis-infected patients by both serologic techniques. Eighty-four patients had serologic evaluations before and 12 weeks after treatment with meglumine antimoniate, 20 mg/kg/day for 20 days. Significant lower optic density values were observed after treatment with both species independent of cure or failure. Our data showed that L. (V.) braziliensis induces a higher antibody response against L. (L.) amazonensis antigens than L. (V.) guyanensis and that down-modulation of the antibody response occurs shortly during disease evolution after treatment. Moreover the data support the use of ELISA as a better tool for detection of antibodies in CL.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-08-28T19:58:10Z No. of bitstreams: 1 (176).pdf: 103631 bytes, checksum: 4a2ab50252ad27e6e459a3782a6004e0 (MD5)Made available in DSpace on 2012-08-28T19:58:10Z (GMT). No. of bitstreams: 1 (176).pdf: 103631 bytes, checksum: 4a2ab50252ad27e6e459a3782a6004e0 (MD5) Previous issue date: 2005-02Elsevierhttp://dx.doi.org/10.1016/j.actatropica.2004.09.005reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACutaneous leishmaniasisAntibody responseIndirect immunofluorescent assayELISALeishmania (Viannia) braziliensisLeishmania (Viannia) guyanensisBrazilAntibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in BrazilActa Tropicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessRomero, Gustavo Adolfo SierraOrge, Maria de la Glória OrgeGuerra, Marcus Vinitius de FariasPaes, Marcilene GomesMacêdo, Vanize de OliveiraCarvalho Filho, Edgar Marcelino deRomero, Gustavo Adolfo SierraOrge, Maria de la Glória OrgeGuerra, Marcus Vinitius de FariasPaes, Marcilene GomesMacêdo, Vanize de OliveiraCarvalho Filho, Edgar Marcelino deORIGINAL(176).pdf(176).pdfapplication/pdf103631https://repositorio.ufba.br/bitstream/ri/6643/1/%28176%29.pdf4a2ab50252ad27e6e459a3782a6004e0MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6643/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(176).pdf.txt(176).pdf.txtExtracted texttext/plain31346https://repositorio.ufba.br/bitstream/ri/6643/3/%28176%29.pdf.txtba213127c776ed33a1e1e5d6adf2d215MD53ri/66432022-07-05 14:03:11.237oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttps://repositorio.ufba.br/oai/requestrepositorio@ufba.bropendoar:19322022-07-05T17:03:11Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
score 15,301629

Registros relacionados