Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
For an adequate blood supply to support metabolic demands, vertebrates regulate blood pressure to maintain sufficient perfusion to avoid ischemia and other tissue damage like edema. Using a pharmacological approach (phenylephrine and sodium nitroprusside) we investigated baroreflex sensitivity at 15...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/126091 |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S1095643314002025 http://hdl.handle.net/11449/126091 |
| Access Level: | acceso abierto |
| Palabra clave: | Baroreflex sensitivity Amphibians Blood pressure Sodium nitroprusside Phenylephrine |
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Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideriBaroreflex sensitivityAmphibiansBlood pressureSodium nitroprussidePhenylephrineFor an adequate blood supply to support metabolic demands, vertebrates regulate blood pressure to maintain sufficient perfusion to avoid ischemia and other tissue damage like edema. Using a pharmacological approach (phenylephrine and sodium nitroprusside) we investigated baroreflex sensitivity at 15, 25, and 30 °C in toads Rhinella schneideri. Baroreflex sensitivity presented a high thermal dependence (Q10 = 1.9–4.1), and the HR– baroreflex curve was shifted up and to the right as temperature increased from 15 to 30 °C. Baroreflex variables, namely, HR range, gain50 (maximal gain) and normalized gain50 increased 206, 235, and 160% from 15 to 30 °C, respectively. The cardiac limb of the baroreflex response to pharmacological treatments was significantly blunted after full autonomic blockade. In addition, there was a clear baroreflex–HR response mainly to hypotension at all three temperatures tested. These findings indicate that toads present temperature dependence for cardiac limb of the barostatic response and the cardiac baroreflex response in R. schneideri is primarily hypotensive rather than hypertensive as well as crocodilians and mammals. Thus, the cardiac baroreflex compensation to changes in arterial pressure might present different patterns among amphibian species, since the previously reported bradycardic compensation to hypertension in some anurans was not observed in the toad used in the present study.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Jaboticabal, Via de acesso Prof. Paulo D Castellane, Rural, CEP 14884-900, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Jaboticabal, Via de acesso Prof. Paulo D Castellane, Rural, CEP 14884-900, SP, BrasilFAPESP: 2008/57712-4FAPESP: 2012/17379-0Universidade Estadual Paulista (Unesp)2015-08-06T16:13:55Z2015-08-06T16:13:55Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article81-88http://www.sciencedirect.com/science/article/pii/S1095643314002025Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, v. 179, p. 81-88, 2015.1095-6433http://hdl.handle.net/11449/12609110.1016/j.cbpa.2014.09.027585045346899449701699673780714260000-0003-1810-5313[3]Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengComparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology2.2580,836info:eu-repo/semantics/openAccessZena, Lucas A. [UNESP]Gargaglioni, Luciane H. [UNESP]Bícego, Kênia Cardoso [UNESP]2025-10-22T09:30:32Zoai:repositorio.unesp.br:11449/126091Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-10-22T09:30:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri |
| title |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri |
| spellingShingle |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri Zena, Lucas A. [UNESP] Baroreflex sensitivity Amphibians Blood pressure Sodium nitroprusside Phenylephrine |
| title_short |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri |
| title_full |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri |
| title_fullStr |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri |
| title_full_unstemmed |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri |
| title_sort |
Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri |
| dc.creator.none.fl_str_mv |
Zena, Lucas A. [UNESP] Gargaglioni, Luciane H. [UNESP] Bícego, Kênia Cardoso [UNESP] |
| author |
Zena, Lucas A. [UNESP] |
| author_facet |
Zena, Lucas A. [UNESP] Gargaglioni, Luciane H. [UNESP] Bícego, Kênia Cardoso [UNESP] |
| author_role |
author |
| author2 |
Gargaglioni, Luciane H. [UNESP] Bícego, Kênia Cardoso [UNESP] |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.subject.por.fl_str_mv |
Baroreflex sensitivity Amphibians Blood pressure Sodium nitroprusside Phenylephrine |
| topic |
Baroreflex sensitivity Amphibians Blood pressure Sodium nitroprusside Phenylephrine |
| description |
For an adequate blood supply to support metabolic demands, vertebrates regulate blood pressure to maintain sufficient perfusion to avoid ischemia and other tissue damage like edema. Using a pharmacological approach (phenylephrine and sodium nitroprusside) we investigated baroreflex sensitivity at 15, 25, and 30 °C in toads Rhinella schneideri. Baroreflex sensitivity presented a high thermal dependence (Q10 = 1.9–4.1), and the HR– baroreflex curve was shifted up and to the right as temperature increased from 15 to 30 °C. Baroreflex variables, namely, HR range, gain50 (maximal gain) and normalized gain50 increased 206, 235, and 160% from 15 to 30 °C, respectively. The cardiac limb of the baroreflex response to pharmacological treatments was significantly blunted after full autonomic blockade. In addition, there was a clear baroreflex–HR response mainly to hypotension at all three temperatures tested. These findings indicate that toads present temperature dependence for cardiac limb of the barostatic response and the cardiac baroreflex response in R. schneideri is primarily hypotensive rather than hypertensive as well as crocodilians and mammals. Thus, the cardiac baroreflex compensation to changes in arterial pressure might present different patterns among amphibian species, since the previously reported bradycardic compensation to hypertension in some anurans was not observed in the toad used in the present study. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-08-06T16:13:55Z 2015-08-06T16:13:55Z 2015 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.sciencedirect.com/science/article/pii/S1095643314002025 Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, v. 179, p. 81-88, 2015. 1095-6433 http://hdl.handle.net/11449/126091 10.1016/j.cbpa.2014.09.027 5850453468994497 0169967378071426 0000-0003-1810-5313[3] |
| url |
http://www.sciencedirect.com/science/article/pii/S1095643314002025 http://hdl.handle.net/11449/126091 |
| identifier_str_mv |
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, v. 179, p. 81-88, 2015. 1095-6433 10.1016/j.cbpa.2014.09.027 5850453468994497 0169967378071426 0000-0003-1810-5313[3] |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 2.258 0,836 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
81-88 |
| dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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repositoriounesp@unesp.br |
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1853671918845034496 |
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15.223283 |