Pythiosis : therapeutic approach

Pythiosis, a disease caused by the oomycete Pythium insidiosum, often presents inefficient response to chemotherapy. It is a consensus that, in spite the several therapeutic protocols, a combination of surgery, chemotherapy and immunotherapy should be used. Surgical excision requires the removal of...

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Autores: Falcão, Christiani Monte Cruz, Zanette, Regis Adriel, Santos, Carlos Eduardo Pereira dos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/234197
Acceso en línea:http://hdl.handle.net/10183/234197
Access Level:acceso abierto
Palabra clave:Pitiose
Pythium
Pythium insidiosum
Review
Chemotherapy
Immunotherapy
Photodynamic therapy
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spelling 2022-01-19T04:36:47Z20152316-9281http://hdl.handle.net/10183/234197000985073Pythiosis, a disease caused by the oomycete Pythium insidiosum, often presents inefficient response to chemotherapy. It is a consensus that, in spite the several therapeutic protocols, a combination of surgery, chemotherapy and immunotherapy should be used. Surgical excision requires the removal of the entire affected area, with a wide margin of safety. The use of antifungal drugs has resulted in variable results, both in vitro and in vivo, and presents low therapeutic efficiency due to differences in the agent characteristics, which differ from true fungi. Immunotherapy is a non-invasive alternative for the treatment of pythiosis, which aims at modifying the immune response of the host, thereby producing an effective response to the agent. Photodynamic therapy has emerged as a promising technique, with good activity against P. insidiosum in vitro and in vivo. However, more studies are necessary to increase the efficiency of the current treatment protocols and consequently improve the cure rates. This paper aims to conduct a review covering the conventional and recent therapeutic methods against P. insidiosum infections.application/pdfengScientific Electronic Archives. Sinop. Vol. 8, no. 3 (Oct. 2015), p. 66-71PitiosePythiumPythium insidiosumReviewChemotherapyImmunotherapyPhotodynamic therapyPythiosis : therapeutic approachinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSFalcão, Christiani Monte CruzZanette, Regis AdrielSantos, Carlos Eduardo Pereira dosTEXT000985073.pdf.txt000985073.pdf.txtExtracted Texttext/plain30507http://www.lume.ufrgs.br/bitstream/10183/234197/2/000985073.pdf.txt274755f80664343ab9093c6e63bb93bfMD52ORIGINAL000985073.pdfTexto completo (inglês)application/pdf291441http://www.lume.ufrgs.br/bitstream/10183/234197/1/000985073.pdf25cd53cbe87a38059705ba95867a02f3MD5110183/2341972022-03-26 05:05:08.46496oai:www.lume.ufrgs.br:10183/234197Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2022-03-26T08:05:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Pythiosis : therapeutic approach
title Pythiosis : therapeutic approach
spellingShingle Pythiosis : therapeutic approach
Falcão, Christiani Monte Cruz
Pitiose
Pythium
Pythium insidiosum
Review
Chemotherapy
Immunotherapy
Photodynamic therapy
title_short Pythiosis : therapeutic approach
title_full Pythiosis : therapeutic approach
title_fullStr Pythiosis : therapeutic approach
title_full_unstemmed Pythiosis : therapeutic approach
title_sort Pythiosis : therapeutic approach
dc.creator.none.fl_str_mv Falcão, Christiani Monte Cruz
Zanette, Regis Adriel
Santos, Carlos Eduardo Pereira dos
author Falcão, Christiani Monte Cruz
author_facet Falcão, Christiani Monte Cruz
Zanette, Regis Adriel
Santos, Carlos Eduardo Pereira dos
author_role author
author2 Zanette, Regis Adriel
Santos, Carlos Eduardo Pereira dos
author2_role author
author
dc.subject.por.fl_str_mv Pitiose
Pythium
topic Pitiose
Pythium
Pythium insidiosum
Review
Chemotherapy
Immunotherapy
Photodynamic therapy
dc.subject.eng.fl_str_mv Pythium insidiosum
Review
Chemotherapy
Immunotherapy
Photodynamic therapy
description Pythiosis, a disease caused by the oomycete Pythium insidiosum, often presents inefficient response to chemotherapy. It is a consensus that, in spite the several therapeutic protocols, a combination of surgery, chemotherapy and immunotherapy should be used. Surgical excision requires the removal of the entire affected area, with a wide margin of safety. The use of antifungal drugs has resulted in variable results, both in vitro and in vivo, and presents low therapeutic efficiency due to differences in the agent characteristics, which differ from true fungi. Immunotherapy is a non-invasive alternative for the treatment of pythiosis, which aims at modifying the immune response of the host, thereby producing an effective response to the agent. Photodynamic therapy has emerged as a promising technique, with good activity against P. insidiosum in vitro and in vivo. However, more studies are necessary to increase the efficiency of the current treatment protocols and consequently improve the cure rates. This paper aims to conduct a review covering the conventional and recent therapeutic methods against P. insidiosum infections.
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