Experimental model of gastroesophageal reflux in rats
PURPOSE: To develop an experimental model of gastroesophageal reflux in rats. METHODS: Sixty Wistar rats underwent surgery and were assigned to one of the three groups of twenty animals each. The animals in group A underwent total esophageal myectomy and, in group (B), underwent partial myectomy. Th...
| Autores: | , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2005 |
| País: | Brasil |
| Recursos: | Universidade Federal de São Paulo (UNIFESP) |
| Repositório: | Repositório Institucional da UNIFESP |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/2776 |
| Acesso em linha: | http://dx.doi.org/10.1590/S0102-86502005000600008 http://repositorio.unifesp.br/handle/11600/2776 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Gastroesophageal Reflux Esophagitis Peptic Animal Experimentation Refluxo Gastroesofágico Esofagite Péptica Experimentação Animal |
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Experimental model of gastroesophageal reflux in ratsModelo experimental de refluxo gastroesofágico em ratosGastroesophageal RefluxEsophagitisPepticAnimal ExperimentationRefluxo GastroesofágicoEsofagite PépticaExperimentação AnimalPURPOSE: To develop an experimental model of gastroesophageal reflux in rats. METHODS: Sixty Wistar rats underwent surgery and were assigned to one of the three groups of twenty animals each. The animals in group A underwent total esophageal myectomy and, in group (B), underwent partial myectomy. The third group was the control group (C). A contrast radiographic study of the esophagus was performed to evaluate gastroesophageal reflux. The anatomopathological study of the esophagus was used to evaluate esophagitis. RESULTS: During the 30-day postoperative follow-up, 14 animals in group A presented with reflux of barium in the esophagus. The presence of barium in the esophagus was observed in 7 animals in group B and in 2 animals in the control group. The result of the histopathology examination was controversial. A marked weight loss in the rats undergoing total myectomy was observed, however there was no significant statistical difference. CONCLUSION: Total myectomy in the lower third of the esophagus caused gastroesophageal reflux in the majority of the animals.OBJETIVO: Desenvolver um modelo experimental de refluxo gastroesofágico em ratos. MÉTODOS: Sessenta ratos, Wistar, foram operados e distribuídos em três grupos de vinte animais. Os animais foram submetidos a miectomia total do esôfago em um grupo(A), e em outro grupo foram submetidos a miectomia parcial(B). O terceiro grupo foi o grupo controle(C). Para avaliar o refluxo gastroesofágico realizou-se o estudo radiológico contrastado do esôfago. O estudo anátomo-patológico do esôfago foi utilizado para avaliar esofagite. RESULTADOS: Durante os 30 dias de pós-operatório, 14 animais do grupo A apresentaram refluxo de Bário no esôfago. Em 07 animais do grupo B e em 02 do grupo controle, foram observados a presença de Bário no esôfago. O resultado do histopatológico foi controverso. Observou-se perda ponderal importante nos ratos submetidos a miectomia total, porém não existiu diferença estatística. CONCLUSÃO: A miectomia total realizada no terço inferior do esôfago provocou refluxo gastroesofágico na maioria dos animais.UNCISAL Escola de Ciências Médicas de AlagoasUNIFESPUNIFESP, EPM, São Paulo, BrazilSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUNCISAL Escola de Ciências Médicas de AlagoasUniversidade Federal de São Paulo (UNIFESP)2015-06-14T13:31:49Z2015-06-14T13:31:49Z2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion437-444application/pdfhttp://dx.doi.org/10.1590/S0102-86502005000600008Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 6, p. 437-444, 2005.10.1590/S0102-86502005000600008S0102-86502005000600008.pdf0102-8650S0102-86502005000600008http://repositorio.unifesp.br/handle/11600/2776ark:/48912/001300001xc4sengActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPGaia Filho, Edmilson Vieira [UNIFESP]Goldenberg, Alberto [UNIFESP]Costa, Henrique Oliveira2024-08-04T14:53:44Zoai:repositorio.unifesp.br:11600/2776Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T14:53:44Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Experimental model of gastroesophageal reflux in rats Modelo experimental de refluxo gastroesofágico em ratos |
| title |
Experimental model of gastroesophageal reflux in rats |
| spellingShingle |
Experimental model of gastroesophageal reflux in rats Gaia Filho, Edmilson Vieira [UNIFESP] Gastroesophageal Reflux Esophagitis Peptic Animal Experimentation Refluxo Gastroesofágico Esofagite Péptica Experimentação Animal |
| title_short |
Experimental model of gastroesophageal reflux in rats |
| title_full |
Experimental model of gastroesophageal reflux in rats |
| title_fullStr |
Experimental model of gastroesophageal reflux in rats |
| title_full_unstemmed |
Experimental model of gastroesophageal reflux in rats |
| title_sort |
Experimental model of gastroesophageal reflux in rats |
| dc.creator.none.fl_str_mv |
Gaia Filho, Edmilson Vieira [UNIFESP] Goldenberg, Alberto [UNIFESP] Costa, Henrique Oliveira |
| author |
Gaia Filho, Edmilson Vieira [UNIFESP] |
| author_facet |
Gaia Filho, Edmilson Vieira [UNIFESP] Goldenberg, Alberto [UNIFESP] Costa, Henrique Oliveira |
| author_role |
author |
| author2 |
Goldenberg, Alberto [UNIFESP] Costa, Henrique Oliveira |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
UNCISAL Escola de Ciências Médicas de Alagoas Universidade Federal de São Paulo (UNIFESP) |
| dc.subject.por.fl_str_mv |
Gastroesophageal Reflux Esophagitis Peptic Animal Experimentation Refluxo Gastroesofágico Esofagite Péptica Experimentação Animal |
| topic |
Gastroesophageal Reflux Esophagitis Peptic Animal Experimentation Refluxo Gastroesofágico Esofagite Péptica Experimentação Animal |
| description |
PURPOSE: To develop an experimental model of gastroesophageal reflux in rats. METHODS: Sixty Wistar rats underwent surgery and were assigned to one of the three groups of twenty animals each. The animals in group A underwent total esophageal myectomy and, in group (B), underwent partial myectomy. The third group was the control group (C). A contrast radiographic study of the esophagus was performed to evaluate gastroesophageal reflux. The anatomopathological study of the esophagus was used to evaluate esophagitis. RESULTS: During the 30-day postoperative follow-up, 14 animals in group A presented with reflux of barium in the esophagus. The presence of barium in the esophagus was observed in 7 animals in group B and in 2 animals in the control group. The result of the histopathology examination was controversial. A marked weight loss in the rats undergoing total myectomy was observed, however there was no significant statistical difference. CONCLUSION: Total myectomy in the lower third of the esophagus caused gastroesophageal reflux in the majority of the animals. |
| publishDate |
2005 |
| dc.date.none.fl_str_mv |
2005-12-01 2015-06-14T13:31:49Z 2015-06-14T13:31:49Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502005000600008 Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 6, p. 437-444, 2005. 10.1590/S0102-86502005000600008 S0102-86502005000600008.pdf 0102-8650 S0102-86502005000600008 http://repositorio.unifesp.br/handle/11600/2776 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300001xc4s |
| url |
http://dx.doi.org/10.1590/S0102-86502005000600008 http://repositorio.unifesp.br/handle/11600/2776 |
| identifier_str_mv |
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 6, p. 437-444, 2005. 10.1590/S0102-86502005000600008 S0102-86502005000600008.pdf 0102-8650 S0102-86502005000600008 ark:/48912/001300001xc4s |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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437-444 application/pdf |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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15.228081 |