Human exposure to mercury and its hematological effects: a systematic review

Mercury is a metal found in the environment from natural and anthropogenic sources. It is highly toxic to ecosystems and living beings. Most human exposures come from ingestion of contaminated seafood, outgassing from dental amalgam or occupational exposure (e.g. gold mining), among other cases. Lar...

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Autores: Vianna, Angélica dos Santos, Matos, Elisabete Pedra de, Jesus, Iracina Maura de, Asmus, Carmen Ildes Rodrigues Fróes, Câmara, Volney de Magalhães
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Brasil
Institución:Instituto Evandro Chagas (IEC)
Repositorio:Repositório Digital do Instituto Evandro Chagas (Patuá)
Idioma:inglés
OAI Identifier:oai:patua.iec.gov.br:iec/3611
Acceso en línea:https://patua.iec.gov.br/handle/iec/3611
Access Level:acceso abierto
Palabra clave:Mercúrio / toxicidade
Mercúrio / sangue
Intoxicação por Mercúrio
Mercúrio / efeitos adversos
Contagem de Células Sanguíneas
Intoxicação por Metais Pesados
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repository_id_str
dc.title.pt_BR.fl_str_mv Human exposure to mercury and its hematological effects: a systematic review
title Human exposure to mercury and its hematological effects: a systematic review
spellingShingle Human exposure to mercury and its hematological effects: a systematic review
Vianna, Angélica dos Santos
Mercúrio / toxicidade
Mercúrio / sangue
Intoxicação por Mercúrio
Mercúrio / efeitos adversos
Contagem de Células Sanguíneas
Intoxicação por Metais Pesados
title_short Human exposure to mercury and its hematological effects: a systematic review
title_full Human exposure to mercury and its hematological effects: a systematic review
title_fullStr Human exposure to mercury and its hematological effects: a systematic review
title_full_unstemmed Human exposure to mercury and its hematological effects: a systematic review
title_sort Human exposure to mercury and its hematological effects: a systematic review
dc.creator.none.fl_str_mv Vianna, Angélica dos Santos
Matos, Elisabete Pedra de
Jesus, Iracina Maura de
Asmus, Carmen Ildes Rodrigues Fróes
Câmara, Volney de Magalhães
author Vianna, Angélica dos Santos
author_facet Vianna, Angélica dos Santos
Matos, Elisabete Pedra de
Jesus, Iracina Maura de
Asmus, Carmen Ildes Rodrigues Fróes
Câmara, Volney de Magalhães
author_role author
author2 Matos, Elisabete Pedra de
Jesus, Iracina Maura de
Asmus, Carmen Ildes Rodrigues Fróes
Câmara, Volney de Magalhães
author2_role author
author
author
author
dc.subject.decsPrimary.pt_BR.fl_str_mv Mercúrio / toxicidade
Mercúrio / sangue
Intoxicação por Mercúrio
Mercúrio / efeitos adversos
Contagem de Células Sanguíneas
Intoxicação por Metais Pesados
topic Mercúrio / toxicidade
Mercúrio / sangue
Intoxicação por Mercúrio
Mercúrio / efeitos adversos
Contagem de Células Sanguíneas
Intoxicação por Metais Pesados
description Mercury is a metal found in the environment from natural and anthropogenic sources. It is highly toxic to ecosystems and living beings. Most human exposures come from ingestion of contaminated seafood, outgassing from dental amalgam or occupational exposure (e.g. gold mining), among other cases. Large populations are exposed to mercury, making it a very important issue from the public health perspective. Adverse health effects are commonly seen in the nervous system, but every organ is a potential target, such as the bone marrow. The main goal of this study was to assess the available evidence on human exposure to mercury and its hematological effects. A search strategy was constructed, including key terms (MeSH, text word and equivalents) for querying 2 repositories of master dissertation and PhD thesis (Fiocruz/ARCA and University of São Paulo) and 4 different electronic databases: BVS/ LILACS, MEDLINE/PubMed, Scopus and TOXLINE/NIH, for articles published from 1950 to February 2018. There was no language restriction and a tool (EPHPP) was used to assess the quality of included studies. According to pre-established criteria, 80 studies were retrieved, all of them observational (48 case reports, 24 cross-sectional, 6 case series and 2 cohorts), comprising 9,284 people. Despite the fact that most exposed ones (6,012) had normal blood cell count and mercury hematological effects did not seem very usual (1,914 cases: 14 severe and 29 deaths), three studies reported association (β) for anemia, lymphopenia, neutrophilia and basophilia. We concluded that the gathered information pointed to mercury hematotoxic effects, some of them may be serious and even fatal.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-02-25T18:33:27Z
dc.date.available.fl_str_mv 2019-02-25T18:33:27Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv VIANNA, Angélica dos Santos et al. Human exposure to mercury and its hematological effects: a systematic review. Cadernos de Saúde Pública, v. 35, n. 2, p. 1-22, e00091618, Feb. 2019.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/3611
dc.identifier.issn.-.fl_str_mv 0102-311X
dc.identifier.doi.-.fl_str_mv 10.1590/0102-311x00091618
identifier_str_mv VIANNA, Angélica dos Santos et al. Human exposure to mercury and its hematological effects: a systematic review. Cadernos de Saúde Pública, v. 35, n. 2, p. 1-22, e00091618, Feb. 2019.
0102-311X
10.1590/0102-311x00091618
url https://patua.iec.gov.br/handle/iec/3611
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública.
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
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spelling 2019-02-25T18:33:27Z2019-02-25T18:33:27Z2019VIANNA, Angélica dos Santos et al. Human exposure to mercury and its hematological effects: a systematic review. Cadernos de Saúde Pública, v. 35, n. 2, p. 1-22, e00091618, Feb. 2019.0102-311Xhttps://patua.iec.gov.br/handle/iec/361110.1590/0102-311x00091618Mercury is a metal found in the environment from natural and anthropogenic sources. It is highly toxic to ecosystems and living beings. Most human exposures come from ingestion of contaminated seafood, outgassing from dental amalgam or occupational exposure (e.g. gold mining), among other cases. Large populations are exposed to mercury, making it a very important issue from the public health perspective. Adverse health effects are commonly seen in the nervous system, but every organ is a potential target, such as the bone marrow. The main goal of this study was to assess the available evidence on human exposure to mercury and its hematological effects. A search strategy was constructed, including key terms (MeSH, text word and equivalents) for querying 2 repositories of master dissertation and PhD thesis (Fiocruz/ARCA and University of São Paulo) and 4 different electronic databases: BVS/ LILACS, MEDLINE/PubMed, Scopus and TOXLINE/NIH, for articles published from 1950 to February 2018. There was no language restriction and a tool (EPHPP) was used to assess the quality of included studies. According to pre-established criteria, 80 studies were retrieved, all of them observational (48 case reports, 24 cross-sectional, 6 case series and 2 cohorts), comprising 9,284 people. Despite the fact that most exposed ones (6,012) had normal blood cell count and mercury hematological effects did not seem very usual (1,914 cases: 14 severe and 29 deaths), three studies reported association (β) for anemia, lymphopenia, neutrophilia and basophilia. We concluded that the gathered information pointed to mercury hematotoxic effects, some of them may be serious and even fatal.Universidade Federal do Rio de Janeiro. Instituto de Estudos de Saúde Coletiva. Rio de Janeiro, RJ, Brasil.Pesquisadora Independente. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Estudos de Saúde Coletiva. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Estudos de Saúde Coletiva. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.engFundação Oswaldo Cruz. 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