Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral
Abstract: This work presents the synthesis as well as the antitumor effect in vitro in bladder cancer cells 5637 of a new class of 5'-arylcalcogenyl-3'-(4-phenylselenoalkyl- 1,2,3-triazol-1-yl)-thymidine derivatives of AZT. The optimization of the reaction conditions, such as the catalyst...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | Brasil |
| Institución: | Universidade Federal de Santa Maria (UFSM) |
| Repositorio: | Manancial - Repositório Digital da UFSM |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufsm.br:1/20537 |
| Acceso en línea: | http://repositorio.ufsm.br/handle/1/20537 |
| Access Level: | acceso abierto |
| Palabra clave: | Análogos nucleosídicos Heterociclo 1,2,3-triazol Organocalcogênios Atividade antitumoral Nucleosidic analogues Heterocycle 1,2,3-triazole Organocalcogen Antitumor activity CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
| Sumario: | Abstract: This work presents the synthesis as well as the antitumor effect in vitro in bladder cancer cells 5637 of a new class of 5'-arylcalcogenyl-3'-(4-phenylselenoalkyl- 1,2,3-triazol-1-yl)-thymidine derivatives of AZT. The optimization of the reaction conditions, such as the catalyst and solvent, for the reaction of 1,3-dipolar cycloaddition in the formation of the 1,2,3-triazole heterocycle was also performed. The synthesis of the new molecules proved to be efficient, being obtained through a convergent route in good to excellent yields (68 - 94%). |
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