Drug resistance evolution of Pseudomonas aeruginosa and Acinetobacter baumannii in intensive care units
ABSTRACT The objective of this study was to describe the susceptibility of A. baumannii and P. aeruginosa, analyze the trend in bacterial resistance and use of antimicrobial agents. This retrospective, descriptive, cross-sectional study was performed in the adult intensive care units of a large-scal...
| Authors: | , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2013 |
| Country: | Brasil |
| Institution: | Universidade Federal de Goiás (UFG) |
| Repository: | Revista Eletrônica de Enfermagem |
| Language: | Portuguese |
| OAI Identifier: | oai:ojs.revistas.ufg.br:article/22031 |
| Online Access: | https://revistas.ufg.br/fen/article/view/22031 |
| Access Level: | Open access |
| Keyword: | Pseudomonas aeruginosa Acinetobacter baumannii Drug Resistance Anti-Infective Agents Cross Infection Resistencia a Medicamentos Antiinfecciosos Infección Hospitalaria Resistência a Medicamentos Anti-Infecciosos Infecção Hospitalar |
| Summary: | ABSTRACT The objective of this study was to describe the susceptibility of A. baumannii and P. aeruginosa, analyze the trend in bacterial resistance and use of antimicrobial agents. This retrospective, descriptive, cross-sectional study was performed in the adult intensive care units of a large-scale public teaching hospital, within the Brazilian Unified Health System (SUS). A total of 121 cases of infection by P. aeruginosa and A. baumannii were identified. A high mean initial resistance rate was observed for both microorganisms. A significant increase was observed in resistance to amikacin in A. baumannii. There was an increase in the consumption of amikacin, imipenem, and piperacillin-tazobactam in P. aeruginosa infections, and of imipenem in A. baumannii infections. No correlation was found between bacterial resistance and antimicrobial use. Higher mortality rates and longer length of stay were observed in the studied group, and bacterial resistance was high. Furthermore, there was an increase in the use of amikacin, imipenem and piperacillin-tazobactam. Descriptors: Pseudomonas aeruginosa; Acinetobacter baumannii; Drug Resistance; Anti-Infective Agents; Cross Infection. |
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