Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ liga...

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Bibliographic Details
Authors: Elia, Evelin Mariel, Pustovrh, María Carolina, Amalfi, Sabrina, Devoto, Luigi, Motta, Alicia Beatriz
Format: article
Status:Published version
Publication Date:2011
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/67730
Online Access:http://hdl.handle.net/11336/67730
Access Level:Open access
Keyword:Lipoxygenases
Metformin
Peroxisome Proliferator Activated Receptor Gamma
Polycystic Ovary Syndrome
Uterus
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Description
Summary:Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect.

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