Synthesis and anticonvulsant activity of amino acid-derived sulfamides

Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimen...

Descripción completa

Detalles Bibliográficos
Autores: Gavernet, Luciana, Elvira, Juan E., Samaja, Gisela, Pastore, Valentina, Sella Cravero, Mariana, Enrique, Andrea Verónica, Estiú, Guillermina, Bruno Blanch, Luis Enrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/123431
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/123431
Access Level:acceso abierto
Palabra clave:Química
Sulfamides
Anticonvulsant compounds
Descripción
Sumario:Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).

Similares en LA Referencia