Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata

Fully consolidated associative memories may be altered by alternative retrieval dependent memory processes. While a brief exposure to the conditioned stimulus (CS) can trigger reconsolidation of the original memory, a prolonged CS exposure will trigger memory extinction. The conditioned response is...

Descripción completa

Detalles Bibliográficos
Autores: Merlo, Santiago Abel, Santos, María Jimena, Pedreira, Maria Eugenia, Merlo, Emiliano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/142321
Acceso en línea:http://hdl.handle.net/11336/142321
Access Level:acceso abierto
Palabra clave:ASSOCIATIVE MEMORY
CYCLOHEXIMIDE
EXTINCTION
LIMBO
NEOHELICE GRANULATA
RECONSOLIDATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
id AR_94e4ae80fb53dacf4afa29d75859a81d
oai_identifier_str oai:ri.conicet.gov.ar:11336/142321
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
title Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
spellingShingle Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
Merlo, Santiago Abel
ASSOCIATIVE MEMORY
CYCLOHEXIMIDE
EXTINCTION
LIMBO
NEOHELICE GRANULATA
RECONSOLIDATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
title_full Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
title_fullStr Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
title_full_unstemmed Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
title_sort Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata
dc.creator.none.fl_str_mv Merlo, Santiago Abel
Santos, María Jimena
Pedreira, Maria Eugenia
Merlo, Emiliano
author Merlo, Santiago Abel
author_facet Merlo, Santiago Abel
Santos, María Jimena
Pedreira, Maria Eugenia
Merlo, Emiliano
author_role author
author2 Santos, María Jimena
Pedreira, Maria Eugenia
Merlo, Emiliano
author2_role author
author
author
dc.subject.none.fl_str_mv ASSOCIATIVE MEMORY
CYCLOHEXIMIDE
EXTINCTION
LIMBO
NEOHELICE GRANULATA
RECONSOLIDATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic ASSOCIATIVE MEMORY
CYCLOHEXIMIDE
EXTINCTION
LIMBO
NEOHELICE GRANULATA
RECONSOLIDATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Fully consolidated associative memories may be altered by alternative retrieval dependent memory processes. While a brief exposure to the conditioned stimulus (CS) can trigger reconsolidation of the original memory, a prolonged CS exposure will trigger memory extinction. The conditioned response is maintained after reconsolidation, but is inhibited after extinction, presumably by the formation of a new inhibitory memory trace. In rats and humans, it has been shown that CS exposure of intermediate duration leave the memory in an insensitive or limbo state. Limbo is characterised by the absence of reconsolidation or extinction. Here we investigated the evolutionary conserved nature of limbo using a contextual Pavlovian conditioning (CPC) memory paradigm in the crab Neohelice granulata. In animals with fully consolidated CPC memory, systemic administration of the protein synthesis inhibitor cycloheximide after 1 CS presentation disrupted the memory, presumably by interfering with memory reconsolidation. The same intervention given after 320 CSs prevented CPC memory extinction. Cycloheximide had no behavioural effect when administered after 80 CS presentations, a protocol that failed to extinguish CPC memory. Also, we observed that a stronger CPC memory engaged reconsolidation after 80 CS instead of limbo, indicating that memory strength affects the parametrical conditions to engage either reconsolidation or limbo. Altogether, these results indicate that limbo is an evolutionary conserved memory process segregating reconsolidation from extinction in the number of CSs space. Limbo appears as an intrinsic component of retrieval dependent memory processing, with a key function in the transition from memory maintenance to inhibition.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/142321
Merlo, Santiago Abel; Santos, María Jimena; Pedreira, Maria Eugenia; Merlo, Emiliano; Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata; Pergamon-Elsevier Science Ltd; Neuroscience; 448; 11-2020; 149-159
0306-4522
CONICET Digital
CONICET
url http://hdl.handle.net/11336/142321
identifier_str_mv Merlo, Santiago Abel; Santos, María Jimena; Pedreira, Maria Eugenia; Merlo, Emiliano; Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata; Pergamon-Elsevier Science Ltd; Neuroscience; 448; 11-2020; 149-159
0306-4522
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.neuroscience.2020.09.035
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2020.09.035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194674120884224
spelling Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulataMerlo, Santiago AbelSantos, María JimenaPedreira, Maria EugeniaMerlo, EmilianoASSOCIATIVE MEMORYCYCLOHEXIMIDEEXTINCTIONLIMBONEOHELICE GRANULATARECONSOLIDATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Fully consolidated associative memories may be altered by alternative retrieval dependent memory processes. While a brief exposure to the conditioned stimulus (CS) can trigger reconsolidation of the original memory, a prolonged CS exposure will trigger memory extinction. The conditioned response is maintained after reconsolidation, but is inhibited after extinction, presumably by the formation of a new inhibitory memory trace. In rats and humans, it has been shown that CS exposure of intermediate duration leave the memory in an insensitive or limbo state. Limbo is characterised by the absence of reconsolidation or extinction. Here we investigated the evolutionary conserved nature of limbo using a contextual Pavlovian conditioning (CPC) memory paradigm in the crab Neohelice granulata. In animals with fully consolidated CPC memory, systemic administration of the protein synthesis inhibitor cycloheximide after 1 CS presentation disrupted the memory, presumably by interfering with memory reconsolidation. The same intervention given after 320 CSs prevented CPC memory extinction. Cycloheximide had no behavioural effect when administered after 80 CS presentations, a protocol that failed to extinguish CPC memory. Also, we observed that a stronger CPC memory engaged reconsolidation after 80 CS instead of limbo, indicating that memory strength affects the parametrical conditions to engage either reconsolidation or limbo. Altogether, these results indicate that limbo is an evolutionary conserved memory process segregating reconsolidation from extinction in the number of CSs space. Limbo appears as an intrinsic component of retrieval dependent memory processing, with a key function in the transition from memory maintenance to inhibition.Fil: Merlo, Santiago Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Santos, María Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Merlo, Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. University of Sussex; Reino UnidoPergamon-Elsevier Science Ltd2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142321Merlo, Santiago Abel; Santos, María Jimena; Pedreira, Maria Eugenia; Merlo, Emiliano; Identification of a Novel Retrieval-dependent Memory Process in the Crab Neohelice granulata; Pergamon-Elsevier Science Ltd; Neuroscience; 448; 11-2020; 149-1590306-4522CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.neuroscience.2020.09.035info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2020.09.035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:34:01Zoai:ri.conicet.gov.ar:11336/142321instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:34:01.661CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,198674

Similares en LA Referencia