Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection

Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(...

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Bibliographic Details
Authors: Macchione, Micaela Alejandra, Guerrero-Beltrán, Carlos, Rosso, Anabella Patricia, Euti, Esteban, Martinelli, Marisa, Strumia, Miriam Cristina, Muñoz-Fernández, Maria Ángeles
Format: article
Status:Published version
Publication Date:2019
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/126889
Online Access:http://hdl.handle.net/11336/126889
Access Level:Open access
Keyword:Vinylcaprolactam
HIV
Nanogels
Antiviral behavior
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Description
Summary:Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.

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