Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats

This work characterized the effects of albendazole sulphoxided (ABZSO) on placental and fetal parameters in Wistar rats on day 20of gestation. (ABZSO) was fed in laboratory chow at 0. 2.5. 5. 10. 20 or 30 mg/kg/d from day 6 to 15 of gestation on pregnant rats. Data of resorptions, placental and feta...

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Detalles Bibliográficos
Autores: Teruel, Miriam, Felipe, Antonio Eduardo, Solana, Huga Daniel, Sallovitz, Juan Manuel, Lanusse, Carlos Edmundo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/106502
Acceso en línea:http://hdl.handle.net/11336/106502
Access Level:acceso abierto
Palabra clave:ALBENDAZOLE SULPHOXIDE
WISTAR RATS
TOXICITY
PREGNANCY
https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
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oai_identifier_str oai:ri.conicet.gov.ar:11336/106502
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar RatsTeruel, MiriamFelipe, Antonio EduardoSolana, Huga DanielSallovitz, Juan ManuelLanusse, Carlos EdmundoALBENDAZOLE SULPHOXIDEWISTAR RATSTOXICITYPREGNANCYhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4This work characterized the effects of albendazole sulphoxided (ABZSO) on placental and fetal parameters in Wistar rats on day 20of gestation. (ABZSO) was fed in laboratory chow at 0. 2.5. 5. 10. 20 or 30 mg/kg/d from day 6 to 15 of gestation on pregnant rats. Data of resorptions, placental and fetal characteristics and fetal skeletal malformations were recorded. Resorption percentages in the 20 and 30 mg/kg/d groups were significantly higher compared to the control group. Placentals of (ABZSO) treated rats had lowel weight and smaller size than untreated rats. The fetal weight and size were lower in the 5 mg/kg/d dose compared to no treatment. In the 5, 10 and 20 mg/kg/d groups, reductions in ossificationprocess were observed. ABZSO induced malformations and/or fetal death when orally administered to pregnant rats. This data contributes to characterization of the reproductive toxicity of ABZSO, the main active metabolite of albendazole.Fil: Teruel, Miriam. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Felipe, Antonio Eduardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Solana, Huga Daniel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican College of Veterinary Toxicologists2003-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/106502Teruel, Miriam; Felipe, Antonio Eduardo; Solana, Huga Daniel; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats; American College of Veterinary Toxicologists; Veterinary and Human Toxicology; 45; 3; 6-2003; 131-1360145-6296CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/12776788/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:16:23Zoai:ri.conicet.gov.ar:11336/106502instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:16:23.352CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
title Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
spellingShingle Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
Teruel, Miriam
ALBENDAZOLE SULPHOXIDE
WISTAR RATS
TOXICITY
PREGNANCY
https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
title_short Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
title_full Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
title_fullStr Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
title_full_unstemmed Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
title_sort Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats
dc.creator.none.fl_str_mv Teruel, Miriam
Felipe, Antonio Eduardo
Solana, Huga Daniel
Sallovitz, Juan Manuel
Lanusse, Carlos Edmundo
author Teruel, Miriam
author_facet Teruel, Miriam
Felipe, Antonio Eduardo
Solana, Huga Daniel
Sallovitz, Juan Manuel
Lanusse, Carlos Edmundo
author_role author
author2 Felipe, Antonio Eduardo
Solana, Huga Daniel
Sallovitz, Juan Manuel
Lanusse, Carlos Edmundo
author2_role author
author
author
author
dc.subject.none.fl_str_mv ALBENDAZOLE SULPHOXIDE
WISTAR RATS
TOXICITY
PREGNANCY
https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
topic ALBENDAZOLE SULPHOXIDE
WISTAR RATS
TOXICITY
PREGNANCY
https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
description This work characterized the effects of albendazole sulphoxided (ABZSO) on placental and fetal parameters in Wistar rats on day 20of gestation. (ABZSO) was fed in laboratory chow at 0. 2.5. 5. 10. 20 or 30 mg/kg/d from day 6 to 15 of gestation on pregnant rats. Data of resorptions, placental and fetal characteristics and fetal skeletal malformations were recorded. Resorption percentages in the 20 and 30 mg/kg/d groups were significantly higher compared to the control group. Placentals of (ABZSO) treated rats had lowel weight and smaller size than untreated rats. The fetal weight and size were lower in the 5 mg/kg/d dose compared to no treatment. In the 5, 10 and 20 mg/kg/d groups, reductions in ossificationprocess were observed. ABZSO induced malformations and/or fetal death when orally administered to pregnant rats. This data contributes to characterization of the reproductive toxicity of ABZSO, the main active metabolite of albendazole.
publishDate 2003
dc.date.none.fl_str_mv 2003-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/106502
Teruel, Miriam; Felipe, Antonio Eduardo; Solana, Huga Daniel; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats; American College of Veterinary Toxicologists; Veterinary and Human Toxicology; 45; 3; 6-2003; 131-136
0145-6296
CONICET Digital
CONICET
url http://hdl.handle.net/11336/106502
identifier_str_mv Teruel, Miriam; Felipe, Antonio Eduardo; Solana, Huga Daniel; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Placental and Fetal Toxicity of Albendazole Sulphoxide in Wistar Rats; American College of Veterinary Toxicologists; Veterinary and Human Toxicology; 45; 3; 6-2003; 131-136
0145-6296
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/12776788/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American College of Veterinary Toxicologists
publisher.none.fl_str_mv American College of Veterinary Toxicologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,228081

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