Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins

The reduction of NO• to HNO/NO- under biologically compatible conditions has always been thought as unlikely, mostly because of the negative reduction potential: E°(NO•,H+/HNO) = -0.55 V vs NHE at physiological pH. Nonetheless, during the past decade, several works hinted at the possible NO-to-HNO c...

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Detalhes bibliográficos
Autores: Hamer, Mariana, Suarez, Sebastian, Neuman, Nicolás Ignacio, Álvarez, Lucía, Muñoz, Martina, Marti, Marcelo Adrian, Doctorovich, Fabio
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/39691
Acesso em linha:http://hdl.handle.net/11336/39691
Access Level:acceso abierto
Palavra-chave:Hno
No
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
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network_acronym_str AR
network_name_str Argentina
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dc.title.none.fl_str_mv Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
title Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
spellingShingle Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
Hamer, Mariana
Hno
No
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
title_short Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
title_full Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
title_fullStr Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
title_full_unstemmed Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
title_sort Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins
dc.creator.none.fl_str_mv Hamer, Mariana
Suarez, Sebastian
Neuman, Nicolás Ignacio
Álvarez, Lucía
Muñoz, Martina
Marti, Marcelo Adrian
Doctorovich, Fabio
author Hamer, Mariana
author_facet Hamer, Mariana
Suarez, Sebastian
Neuman, Nicolás Ignacio
Álvarez, Lucía
Muñoz, Martina
Marti, Marcelo Adrian
Doctorovich, Fabio
author_role author
author2 Suarez, Sebastian
Neuman, Nicolás Ignacio
Álvarez, Lucía
Muñoz, Martina
Marti, Marcelo Adrian
Doctorovich, Fabio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Hno
No
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
topic Hno
No
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
description The reduction of NO• to HNO/NO- under biologically compatible conditions has always been thought as unlikely, mostly because of the negative reduction potential: E°(NO•,H+/HNO) = -0.55 V vs NHE at physiological pH. Nonetheless, during the past decade, several works hinted at the possible NO-to-HNO conversion mediated by moderate biological reductants. Very recently, we have shown that the reaction of NO• with ascorbate and aromatic alcohols occurs through a proton-coupled nucleophilic attack (PCNA) of the alcohol to NO•, yielding an intermediate RO-N(H)O• species, which further decomposes to release HNO. For the present work, we decided to inspect whether other common biological aromatic alcohols obtained from foods, such as Vitamin E, or used as over-the-counter drugs, like aspirin, are able to undergo the reaction. The positive results suggest that the conversion of NO to HNO could occur far more commonly than previously expected. Taking these as the starting point, we set to review our and other groups' previous reports on the possible NO-to-HNO conversion mediated by biological compounds including phenolic drugs and vitamins, as well as several thiol-bearing compounds. Analysis of revised data prompted us to ask ourselves the following key questions: What are the most likely physio/pathological conditions for NO•-to-HNO conversion to take place? Which effects usually attributed to NO• are indeed mediated by HNO? These inquiries are discussed in the context of 2 decades of NO and HNO research.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39691
Hamer, Mariana; Suarez, Sebastian; Neuman, Nicolás Ignacio; Álvarez, Lucía; Muñoz, Martina; et al.; Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins; American Chemical Society; Inorganic Chemistry; 54; 19; 8-2015; 9342-9350
0020-1669
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39691
identifier_str_mv Hamer, Mariana; Suarez, Sebastian; Neuman, Nicolás Ignacio; Álvarez, Lucía; Muñoz, Martina; et al.; Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins; American Chemical Society; Inorganic Chemistry; 54; 19; 8-2015; 9342-9350
0020-1669
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.inorgchem.5b01347
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.inorgchem.5b01347
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and VitaminsHamer, MarianaSuarez, SebastianNeuman, Nicolás IgnacioÁlvarez, LucíaMuñoz, MartinaMarti, Marcelo AdrianDoctorovich, FabioHnoNohttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The reduction of NO• to HNO/NO- under biologically compatible conditions has always been thought as unlikely, mostly because of the negative reduction potential: E°(NO•,H+/HNO) = -0.55 V vs NHE at physiological pH. Nonetheless, during the past decade, several works hinted at the possible NO-to-HNO conversion mediated by moderate biological reductants. Very recently, we have shown that the reaction of NO• with ascorbate and aromatic alcohols occurs through a proton-coupled nucleophilic attack (PCNA) of the alcohol to NO•, yielding an intermediate RO-N(H)O• species, which further decomposes to release HNO. For the present work, we decided to inspect whether other common biological aromatic alcohols obtained from foods, such as Vitamin E, or used as over-the-counter drugs, like aspirin, are able to undergo the reaction. The positive results suggest that the conversion of NO to HNO could occur far more commonly than previously expected. Taking these as the starting point, we set to review our and other groups' previous reports on the possible NO-to-HNO conversion mediated by biological compounds including phenolic drugs and vitamins, as well as several thiol-bearing compounds. Analysis of revised data prompted us to ask ourselves the following key questions: What are the most likely physio/pathological conditions for NO•-to-HNO conversion to take place? Which effects usually attributed to NO• are indeed mediated by HNO? These inquiries are discussed in the context of 2 decades of NO and HNO research.Fil: Hamer, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Suarez, Sebastian. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Neuman, Nicolás Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Física; ArgentinaFil: Álvarez, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Muñoz, Martina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Marti, Marcelo Adrian. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Doctorovich, Fabio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaAmerican Chemical Society2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39691Hamer, Mariana; Suarez, Sebastian; Neuman, Nicolás Ignacio; Álvarez, Lucía; Muñoz, Martina; et al.; Discussing Endogenous NO•/HNO Interconversion Aided by Phenolic Drugs and Vitamins; American Chemical Society; Inorganic Chemistry; 54; 19; 8-2015; 9342-93500020-1669CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/acs.inorgchem.5b01347info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.inorgchem.5b01347info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:53:27Zoai:ri.conicet.gov.ar:11336/39691instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:53:28.187CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,228081

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