Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years

Background. Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determin...

ver descrição completa

Detalhes bibliográficos
Autores: Caballero, Mauricio Tomás, Satav, Ashish, Gill, Christopher J., Omer, Saad B., Pieciak, Rachel C., Kazi, Abdul Momin, Simões, Eric Af, Polack, Fernando Pedro
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/155110
Acesso em linha:http://hdl.handle.net/11336/155110
Access Level:acceso abierto
Palavra-chave:CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
id AR_02de0800a354a9ab3cdd76cfef31ac04
oai_identifier_str oai:ri.conicet.gov.ar:11336/155110
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 yearsCaballero, Mauricio TomásSatav, AshishGill, Christopher J.Omer, Saad B.Pieciak, Rachel C.Kazi, Abdul MominSimões, Eric AfPolack, Fernando PedroCHALLENGESCOMMUNITY MORTALITYRESPIRATORY SYNCYTIAL VIRUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background. Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality due to the virus in developing countries is important. Objective. Our aim in this study was to describe the obstacles, gaps, and challenges that investigators face in low-income, vulnerable regions in 4 developing countries on 3 continents. Results. The main obstacles and challenges of ascertaining community mortality due to RSV were defining strategies to consent families for testing before burial, sampling individuals at the household level, supporting bereaved parents with different cultural and religious backgrounds, establishing tailored strategies for studies in challenging settings, and integrating RSV mortality data from nasopharyngeal samples. Conclusion. Detailed logistical planning based on population sociodemographic information, grief counseling, staff training, and a multidisciplinary approach with adequate laboratory infrastructure is critical to successful observational community-based RSV studies.Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Satav, Ashish. Mahatma Gandhi Tribal Hospital; IndiaFil: Gill, Christopher J.. University of Boston. School of Medicine; Estados UnidosFil: Omer, Saad B.. University of Yale. School of Medicine; Estados UnidosFil: Pieciak, Rachel C.. University of Boston. School of Medicine; Estados UnidosFil: Kazi, Abdul Momin. Aga Khan University; PakistánFil: Simões, Eric Af. University of Colorado. School of Medicine; Estados UnidosFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; ArgentinaUniversity of Chicago Press2021-09-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155110Caballero, Mauricio Tomás; Satav, Ashish; Gill, Christopher J.; Omer, Saad B.; Pieciak, Rachel C.; et al.; Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years; University of Chicago Press; Clinical Infectious Diseases; 73; 3; 2-9-2021; 248-2541058-48381537-6591CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/cid/ciab487info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cid/article/73/Supplement_3/S248/6362479info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:36:15Zoai:ri.conicet.gov.ar:11336/155110instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:36:15.664CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
spellingShingle Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
Caballero, Mauricio Tomás
CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_full Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_fullStr Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_full_unstemmed Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_sort Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
dc.creator.none.fl_str_mv Caballero, Mauricio Tomás
Satav, Ashish
Gill, Christopher J.
Omer, Saad B.
Pieciak, Rachel C.
Kazi, Abdul Momin
Simões, Eric Af
Polack, Fernando Pedro
author Caballero, Mauricio Tomás
author_facet Caballero, Mauricio Tomás
Satav, Ashish
Gill, Christopher J.
Omer, Saad B.
Pieciak, Rachel C.
Kazi, Abdul Momin
Simões, Eric Af
Polack, Fernando Pedro
author_role author
author2 Satav, Ashish
Gill, Christopher J.
Omer, Saad B.
Pieciak, Rachel C.
Kazi, Abdul Momin
Simões, Eric Af
Polack, Fernando Pedro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description Background. Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality due to the virus in developing countries is important. Objective. Our aim in this study was to describe the obstacles, gaps, and challenges that investigators face in low-income, vulnerable regions in 4 developing countries on 3 continents. Results. The main obstacles and challenges of ascertaining community mortality due to RSV were defining strategies to consent families for testing before burial, sampling individuals at the household level, supporting bereaved parents with different cultural and religious backgrounds, establishing tailored strategies for studies in challenging settings, and integrating RSV mortality data from nasopharyngeal samples. Conclusion. Detailed logistical planning based on population sociodemographic information, grief counseling, staff training, and a multidisciplinary approach with adequate laboratory infrastructure is critical to successful observational community-based RSV studies.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155110
Caballero, Mauricio Tomás; Satav, Ashish; Gill, Christopher J.; Omer, Saad B.; Pieciak, Rachel C.; et al.; Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years; University of Chicago Press; Clinical Infectious Diseases; 73; 3; 2-9-2021; 248-254
1058-4838
1537-6591
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155110
identifier_str_mv Caballero, Mauricio Tomás; Satav, Ashish; Gill, Christopher J.; Omer, Saad B.; Pieciak, Rachel C.; et al.; Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years; University of Chicago Press; Clinical Infectious Diseases; 73; 3; 2-9-2021; 248-254
1058-4838
1537-6591
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/cid/ciab487
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cid/article/73/Supplement_3/S248/6362479
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194780053274624
score 15,812455

Registos relacionados