The prostaglandin D2 receptor (PTGDR) gene in asthma and allergic diseases

[EN] The prostaglandin D2 receptor (PTGDR) gene has been associated to asthma and related phenotypes by linking and association studies. Functional studies involving animal models and other expression studies based on in vitro cell models also point to a possible role of polymorphisms in the promote...

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Bibliographic Details
Authors: García Solaesa, Virginia, Sanz Lozano, Catalina Sofía, Padrón-Morales, J., Hernández Hernández, Laura, García Sánchez, María Asunción, Rivera-Reigada, M.L., Dávila González, Ignacio Jesús, Lorente-Toledano, F., Isidoro García, María
Format: article
Status:Published version
Publication Date:2014
Country:España
Institution:Universidad de Salamanca (USAL)
Repository:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/158882
Online Access:http://hdl.handle.net/10366/158882
Access Level:Open access
Keyword:Asthma
Atopy
Prostaglandin D(2)
Prostaglandin D(2) receptor
Genetics
Allergy and Immunology
3207.01 Alergias
2409 Genética
alergia e inmunología
genética
Description
Summary:[EN] The prostaglandin D2 receptor (PTGDR) gene has been associated to asthma and related phenotypes by linking and association studies. Functional studies involving animal models and other expression studies based on in vitro cell models also point to a possible role of polymorphisms in the promoter region, in the differential binding of transcription factors, and thus in PTGDR expression, which appear to be associated to the development of asthma or of susceptibility to the disease.

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